USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: PDIA6_HUMAN USC-OGP 2-DE database:  PDIA6_HUMAN PDIA6_HUMAN General information about the entry View entry in simple text format Entry name PDIA6_HUMAN Primary accession number Q15084 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Protein disulfide-isomerase A6; EC=5.3.4.1 {ECO:0000269|PubMed:12204115, ECO:0000269|PubMed:15466936}; AltName: Full=Endoplasmic reticulum protein 5; Short=ER protein 5; Short=ERp5; AltName: Full=Protein disulfide isomerase P5; AltName: Full=Thioredoxin domain-containing protein 7; Flags: Precursor;. Gene name Name=PDIA6 Synonyms=ERP5, P5, TXNDC7 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0567: pI=5.34; Mw=20990 SPOT OGP-0569: pI=5.33; Mw=20483 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0847: pI=5.29; Mw=16741 Cross-references UniProtKB/Swiss-Prot Q15084; PDIA6_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PDIA6_HUMAN Primary accession number Q15084 Secondary accession number(s) B3KY95 B5MCQ5 B7Z254 B7Z4M8 F8WA83 Q53RC7 Q6ZSH5 Q99778 Sequence was last modified on  November 1, 1997 (version 1) Annotations were last modified on  March 15, 2017 (version 187) Name and origin of the protein Description RecName: Full=Protein disulfide-isomerase A6; EC=5.3.4.1 {ECO:0000269|PubMed:12204115, ECO:0000269|PubMed:15466936}; AltName: Full=Endoplasmic reticulum protein 5; Short=ER protein 5; Short=ERp5; AltName: Full=Protein disulfide isomerase P5; AltName: Full=Thioredoxin domain-containing protein 7; Flags: Precursor; Gene name Name=PDIA6 Synonyms=ERP5, P5, TXNDC7 Encoded on Name=PDIA6; Synonyms=ERP5, P5, TXNDC7 Keywords 3D-structure; Alternative splicing; Cell membrane; Chaperone; Complete proteome; Direct protein sequencing; Disulfide bond; Endoplasmic reticulum; Isomerase; Membrane; Phosphoprotein; Polymorphism; Redox-active center; Reference proteome; Repeat; Signal. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL D49489; BAA08450.1; -; mRNA EMBL AK127433; BAC86977.1; -; mRNA EMBL AK131234; BAG54757.1; -; mRNA EMBL AK289428; BAF82117.1; -; mRNA EMBL AK294347; BAH11740.1; -; mRNA EMBL AK297547; BAH12614.1; -; mRNA EMBL AC092687; AAY24070.1; -; Genomic_DNA EMBL CH471053; EAX00950.1; -; Genomic_DNA EMBL BC001312; AAH01312.1; -; mRNA EMBL U79278; AAB50217.1; -; mRNA CCDS CCDS1675.1; -. [Q15084-1]; . CCDS CCDS62852.1; -. [Q15084-3]; . CCDS CCDS62853.1; -. [Q15084-4]; . CCDS CCDS62854.1; -. [Q15084-2]; . CCDS CCDS62855.1; -. [Q15084-5]; . PIR JC4369; JC4369; . RefSeq NP_001269633.1; NM_001282704.1. [Q15084-2]; . RefSeq NP_001269634.1; NM_001282705.1. [Q15084-5]; . RefSeq NP_001269635.1; NM_001282706.1. [Q15084-4]; . RefSeq NP_001269636.1; NM_001282707.1. [Q15084-3]; . RefSeq NP_005733.1; NM_005742.3. [Q15084-1]; . UniGene Hs.212102; -; . UniGene Hs.580464; -; . PDB 1X5D; NMR; -; A=161-280 PDB 3VWW; X-ray; 1.93 A; A/B=25-140 PDB 3W8J; X-ray; 2.10 A; A/B=20-140 PDB 4EF0; X-ray; 1.50 A; A/B=27-140 PDB 4GWR; X-ray; 1.81 A; A/B=160-274 PDBsum 1X5D; -; . PDBsum 3VWW; -; . PDBsum 3W8J; -; . PDBsum 4EF0; -; . PDBsum 4GWR; -; . ProteinModelPortal Q15084; -; . SMR Q15084; -; . BioGrid 115434; 91; . IntAct Q15084; 38; . MINT MINT-3030897; -; . STRING 9606.ENSP00000272227; -; . ChEMBL CHEMBL2146308; -; . iPTMnet Q15084; -; . PhosphoSitePlus Q15084; -; . SwissPalm Q15084; -; . DMDM 2501205; -; . OGP Q15084; -; . REPRODUCTION-2DPAGE IPI00644989; -; . REPRODUCTION-2DPAGE Q15084; -; . EPD Q15084; -; . PaxDb Q15084; -; . PeptideAtlas Q15084; -; . PRIDE Q15084; -; . DNASU 10130; -; . Ensembl ENST00000272227; ENSP00000272227; ENSG00000143870. [Q15084-1]; . Ensembl ENST00000381611; ENSP00000371024; ENSG00000143870. [Q15084-4]; . Ensembl ENST00000404371; ENSP00000385385; ENSG00000143870. [Q15084-2]; . Ensembl ENST00000404824; ENSP00000384459; ENSG00000143870. [Q15084-5]; . Ensembl ENST00000540494; ENSP00000438778; ENSG00000143870. [Q15084-3]; . Ensembl ENST00000617249; ENSP00000481892; ENSG00000143870. [Q15084-2]; . GeneID 10130; -; . KEGG hsa:10130; -; . UCSC uc002rau.5; human. [Q15084-1]; . CTD 10130; -; . DisGeNET 10130; -; . GeneCards PDIA6; -; . HGNC HGNC:30168; PDIA6; . HPA CAB034347; -; . HPA HPA034652; -; . HPA HPA034653; -; . MIM 611099; gene; . neXtProt NX_Q15084; -; . OpenTargets ENSG00000143870; -; . PharmGKB PA134977905; -; . eggNOG KOG0191; Eukaryota; . eggNOG COG0526; LUCA; . GeneTree ENSGT00860000133723; -; . HOGENOM HOG000012631; -; . HOVERGEN HBG053548; -; . InParanoid Q15084; -; . KO K09584; -; . OMA TAHQSKA; -; . OrthoDB EOG091G07Z0; -; . PhylomeDB Q15084; -; . TreeFam TF315231; -; . Reactome R-HSA-381038; XBP1(S) activates chaperone genes; . ChiTaRS PDIA6; human; . EvolutionaryTrace Q15084; -; . GenomeRNAi 10130; -; . PRO PR:Q15084; -; . Proteomes UP000005640; Chromosome 2; . Bgee ENSG00000143870; -; . CleanEx HS_PDIA6; -; . ExpressionAtlas Q15084; baseline and differential; . Genevisible Q15084; HS; . GO GO:0005829; C:cytosol; IDA:HPA; . GO GO:0005783; C:endoplasmic reticulum; TAS:UniProtKB; . GO GO:0034663; C:endoplasmic reticulum chaperone complex; ISS:ParkinsonsUK-UCL; . GO GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell; . GO GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome; . GO GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IDA:UniProtKB; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0042470; C:melanosome; IEA:UniProtKB-SubCell; . GO GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell; . GO GO:0003756; F:protein disulfide isomerase activity; IBA:GO_Central; . GO GO:0043277; P:apoptotic cell clearance; IBA:GO_Central; . GO GO:0045454; P:cell redox homeostasis; IEA:InterPro; . GO GO:0036498; P:IRE1-mediated unfolded protein response; TAS:Reactome; . GO GO:0006457; P:protein folding; TAS:ProtInc; . GO GO:0034976; P:response to endoplasmic reticulum stress; IBA:GO_Central; . Gene3D 3.40.30.10; -; 2; . InterPro IPR005788; Disulphide_isomerase; . InterPro IPR012336; Thioredoxin-like_fold; . InterPro IPR017937; Thioredoxin_CS; . InterPro IPR013766; Thioredoxin_domain; . Pfam PF00085; Thioredoxin; 2; . SUPFAM SSF52833; SSF52833; 3; . TIGRFAMs TIGR01126; pdi_dom; 2; . PROSITE PS00014; ER_TARGET; 1; . PROSITE PS00194; THIOREDOXIN_1; 2; . PROSITE PS51352; THIOREDOXIN_2; 2; .

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